Gottlieb's more recent works showcase a unique synthesis of her modern graphic design background and the vintage botanical renderings of natural scientists. However, her paintings are also unique in their perspective on the traditional floral still life. Stylized flora and fauna are depicted as emanating from a comic book explosion, illustrating what the artist refers to as ''the dire state of the planet'' as faced with species extinction and the resulting biological and ecological ramifications. These violent representations of the artistically typified placid natural world are intended as ''visual eulogies for lost plant life.'' The particular specimens that Gottlieb depicts are in fact extinct and she is able to recreate them only from historical drawings and botanist's descriptions.
Although avant-garde and aesthetically unique, Gottlieb's paintings delineate clear influences from the renowned artists of Pop and Expressionist art. The composition of many of her paintings is reminiscent of Kandinsky's canvas-filling outpours while her bold color palette and black outlines recall Lichtenstein's comic book panels. Her work is also closely related to a more contemporary group of artists, including Alexis Rockman, Rachel Berwick, and Mark Dion, whose pieces also illustrate a coalescence of art and science. Gottlieb's paintings ultimately serve as acknowledgments of brutally lost nature, but simultaneously capture the power of the imagination and a hope for renewal.